Symbol
Name
ID

Nos3
nitric oxide synthase 3, endothelial cell
MGI:97362

Phenotype annotations related to renal/urinary system

Darker colors indicate more annotations

Human Phenotypes	Hypercalciuria	Hematuria	Decreased level of D-mannose in urine	Nephrolithiasis	Renal insufficiency
Disease(s) Associated with NOS3	Hypercalciuria	Hematuria	Decreased level of D-mannose in urine	Nephrolithiasis	Renal insufficiency
Behcet's disease
cystic fibrosis
sickle cell anemia

Mouse Phenotypes

abnormal glomerular capillary endothelium morphology

increased mesangial cell number

increased kidney apoptosis

increased renal tubule apoptosis

renal tubular necrosis

decreased kidney cell proliferation

albuminuria

kidney inflammation

abnormal kidney morphology

abnormal kidney cortex morphology

dilated renal glomerular capsule

abnormal renal glomerulus morphology

expanded mesangial matrix

mesangiolysis

glomerulosclerosis

renal glomerulus fibrosis

renal glomerulus hypertrophy

renal glomerulus lipidosis

abnormal renal tubule epithelium morphology

renal interstitial fibrosis

decreased kidney weight

small kidney

renal hypoplasia

abnormal proximal convoluted tubule morphology

dilated renal tubule

renal cast

kidney degeneration

kidney failure

Availability

Mouse Genotype

Nos3^em1(IMPC)Mbp/Nos3^em1(IMPC)Mbp

Nos3^tm1.2Taka/Nos3^tm1.2Taka

Nos3^tm1Plh/Nos3^tm1Plh

Nos3^tm1Unc/Nos3^tm1Unc

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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